Cytotoxic effect of targeted biodegradable epothilone B and rapamycin co‐loaded nanocarriers on breast cancer cells
| Autor: | Alicja Zajdel, Monika Musiał-Kulik, Adam Wilczok, Janusz Kasperczyk, Katarzyna Jelonek, Anna Kaps |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Cell Survival Proton Magnetic Resonance Spectroscopy 0206 medical engineering Cell Biomedical Engineering Biocompatible Materials Breast Neoplasms macromolecular substances 02 engineering and technology Micelle Biomaterials chemistry.chemical_compound Drug Delivery Systems Breast cancer Biotin Cell Line Tumor medicine Humans Cytotoxic T cell Cytotoxicity Micelles Sirolimus Drug Carriers Cell Death technology industry and agriculture Metals and Alloys 021001 nanoscience & nanotechnology medicine.disease 020601 biomedical engineering medicine.anatomical_structure chemistry Epothilones Drug delivery Ceramics and Composites Cancer research Nanoparticles Female Nanocarriers 0210 nano-technology |
| Zdroj: | Journal of Biomedical Materials Research Part A. 109:1693-1700 |
| ISSN: | 1552-4965 1549-3296 |
| DOI: | 10.1002/jbm.a.37164 |
| Popis: | The new therapeutic solutions for breast cancer treatment are needed, for example, combined therapy consisted of several drugs that characterize different mechanisms of action and modern drug delivery systems. Therefore, we used combination of epothilone B (EpoB) and rapamycin (Rap) to analyze the cytotoxic effect against breast cancer cells (MCF-7; MDA-MB-231). Also, the effect of drugs co-delivered in bioresorbable micelles functionalized with biotin (PLA-PEG-BIO; poly(lactide)-co-poly(ethylene glycol)-biotin) was studied. The comparison of effects of the mixture of free drugs and the micelles co-loaded with EpoB and Rap revealed a significant decrease in the cell metabolic activity and survival. Moreover, the dual drug-loaded PLA-PEG-BIO micelles enhanced the cytotoxicity of EpoB and Rap against the tested cells as compared with the free drugs. The blank PLA-PEG-BIO micelles did not affect the tested cells. We expect that mixture of EpoB and Rap may be promising in breast cancer treatment and PLA-PEG-BIO micelles as carrier of these two drugs can be applicable for successful targeted delivery. |
| Databáze: | OpenAIRE |
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