Impact of Fasting Glycemia on Short-Term Prognosis after Acute Myocardial Infarction
| Autor: | Jean-Claude Beer, Jean Eric Wolf, Hamid Makki, Yves Cottin, Luc Janin-Manificat, Yves Laurent, Bruno Vergès, Gilles Dentan, Marianne Zeller |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Heart disease Endocrinology Diabetes and Metabolism Clinical Biochemistry Myocardial Infarction Sensitivity and Specificity behavioral disciplines and activities Biochemistry Cohort Studies Fasting glucose Endocrinology Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus Prevalence medicine Humans Myocardial infarction Acute mi Aged Cardiovascular mortality business.industry Biochemistry (medical) nutritional and metabolic diseases Fasting Middle Aged Prognosis medicine.disease Impaired fasting glucose ROC Curve Hyperglycemia Heart failure Female Morbidity business hormones hormone substitutes and hormone antagonists psychological phenomena and processes |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 92:2136-2140 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2006-2584 |
| Popis: | The prognosis of patients with acute myocardial infarction (MI), according to the new criteria for impaired fasting glucose (IFG) (FG 100-126 mg/dl), has not been evaluated.A total of 2353 patients with acute MI and surviving at d 5 after admission were analyzed for short-term morbidity and mortality. FG was obtained at d 4 and 5. Patients were classified as diabetes mellitus (known diabetes or FGor = 126 mg/dl), high IFG (110or = FG126 mg/dl), low IFG (100or = FG110 mg/dl), and normal fasting glucose (NFG) (FG100 mg/dl).Among the 2353 patients, 968 (41%) had diabetes mellitus, 262 (11%) had high IFG, 332 (14%) had low IFG, and 791 (34%) had NFG. Compared with NFG patients, 30-d cardiovascular mortality was increased in high but not low IFG subjects. In-hospital heart failure was increased in high IFG subjects (42 vs. 20% for NFG, P0.0001) but not low IFG subjects (21 vs. 20%). High IFG, but not low IFG, was an independent factor associated with 30-d cardiovascular mortality [odds ratio 2.33 (1.55-3.47)] and in-hospital heart failure [odds ratio 1.70 (1.36-2.07)]. The optimal threshold levels of FG on the receiver-operating characteristic curves were 114 and 112 mg/dl to predict mortality and in-hospital heart failure, respectively.The present study, based on a nonselected cohort of MI patients, underscores the high prevalence of IFG (25%) and highlights the clinical relevance of 110 mg/dl, but not 100 mg/dl, as a cutoff value to define the risk for worse outcome. |
| Databáze: | OpenAIRE |
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