Clinical significance of estrogen receptor phosphorylation
| Autor: | Leigh C. Murphy, Srinivas V Seekallu, Peter H. Watson |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Selective Estrogen Receptor Modulators
Proteasome Endopeptidase Complex Cancer Research medicine.medical_specialty Neoplasms Hormone-Dependent Antineoplastic Agents Hormonal Biopsy Endocrinology Diabetes and Metabolism Estrogen receptor Breast Neoplasms Structure-Activity Relationship Endocrinology In vivo Internal medicine medicine Humans Neoplasm Clinical significance Phosphorylation skin and connective tissue diseases business.industry Carcinoma Estrogen Receptor alpha Cancer Estrogens medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic Tamoxifen Treatment Outcome Oncology Drug Resistance Neoplasm Disease Progression Cancer research Female Signal transduction business Protein Kinases Protein Processing Post-Translational Signal Transduction medicine.drug |
| Zdroj: | Endocrine Related Cancer. 18:R1-R14 |
| ISSN: | 1479-6821 1351-0088 |
| Popis: | Multiple sites of phosphorylation on human estrogen receptor α (ERα) have been identified by a variety of methodologies. Now with the emerging availability of phospho-site-specific antibodies to ERα, the relevance of phosphorylation of ERα in human breast cancer in vivo is being explored. Multiple phosphorylated sites in ERα can be detected in multiple breast tumor biopsy samples, providing evidence of their relevance to human breast cancer in vivo. Published data suggest that the detection in primary breast tumors of phosphorylation at some sites in ERα is associated with a better clinical outcome while phosphorylation at other sites is associated with a poorer clinical outcome most often in patients who have been treated with tamoxifen. This suggests the hypothesis that phospho-profiling of ERα in human breast tumors to establish an 'ERα phosphorylation code', may be a more accurate marker of prognosis and/or response to endocrine therapy in human breast cancer. |
| Databáze: | OpenAIRE |
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