Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line
| Autor: | Daniel Butlen, Marie Teixeira, Say Viengchareun, Jérôme Nevoux, Evelyne Ferrary, Marc Lombès, Claudine Cosson |
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| Přispěvatelé: | Lombes, Marc, Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Chirurgie otologique mini-invasive robotisée, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Biochimie [Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service d'Endocrinologie et Maladies de la reproduction, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service d'ORL, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This work was supported by grants from Inserm, Université Paris Diderot, Université Paris-Sud, European Section of Aldosterone Council (ESAC) and a fellowship from the Société Française d'Oto-Rhino-Laryngologie (to JN)., Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR93-Université Paris-Sud - Paris 11 (UP11) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Vasopressin
Receptors Vasopressin Endolymph Biochemistry MESH: Receptors Purinergic P2Y Menière’s disease Mice 0302 clinical medicine Adenosine Triphosphate Catecholamines Structural Biology MESH: Reverse Transcriptase Polymerase Chain Reaction MESH: Adenosine Triphosphate Cyclic AMP MESH: Animals MESH: Cyclic AMP Vasopressin receptor 0303 health sciences endolymph Chemistry Reverse Transcriptase Polymerase Chain Reaction Purinergic receptor Purinergic signalling 3. Good health medicine.anatomical_structure [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs Receptors Purinergic P2Y vestibular cells MESH: Receptors Vasopressin Menière's disease MESH: Vasopressins Adenylyl Cyclases medicine.medical_specialty Vasopressins Blotting Western Biophysics Adenylate kinase MESH: Calcium Signaling Cell Line 03 medical and health sciences vasopressin receptors Internal medicine purinergic receptors MESH: Adenylate Cyclase Genetics medicine otorhinolaryngologic diseases MESH: Catecholamines Animals MESH: Blotting Western Inner ear Calcium Signaling [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs Molecular Biology MESH: Mice 030304 developmental biology Phosphoric Diester Hydrolases Cell Biology MESH: Cell Line Endocrinology Ear Inner MESH: Potassium Potassium sense organs MESH: Phosphoric Diester Hydrolases 030217 neurology & neurosurgery MESH: Ear Inner Low sodium |
| Zdroj: | FEBS Letters FEBS Letters, Wiley, 2011, 585 (17), pp.2703-8. ⟨10.1016/j.febslet.2011.07.025⟩ |
| ISSN: | 0014-5793 1873-3468 |
| DOI: | 10.1016/j.febslet.2011.07.025⟩ |
| Popis: | International audience; A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases. |
| Databáze: | OpenAIRE |
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