MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance

Autor: Marcel Spaargaren, Tomohiro Mizutani, Steven T. Pals, Hans Clevers, Sander P.J. Joosten
Přispěvatelé: Hubrecht Institute for Developmental Biology and Stem Cell Research, Graduate School, Pathology, CCA - Cancer biology and immunology
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Neoplastic Stem Cells/drug effects
Colorectal cancer
Drug Resistance
Drug resistance
Drug Resistance
Neoplasm/drug effects
medicine.disease_cause
Proto-Oncogene Proteins c-met/antagonists & inhibitors
Cell Proliferation/drug effects
Neoplasm/drug effects
ErbB Receptors/antagonists & inhibitors
Epidermal growth factor receptor
Intestinal Mucosa
Mutation
Tumor
biology
Triazines
Gastroenterology
Gefitinib
Colorectal Neoplasms/drug therapy
Proto-Oncogene Proteins c-met
ErbB Receptors
Gefitinib/pharmacology
Pyrazines
Neoplastic Stem Cells
Pyrazines/pharmacology
Signal transduction
Stem cell
Colorectal Neoplasms
Antineoplastic Agents/pharmacology
Signal Transduction
Genes
APC
Intestinal Mucosa/drug effects
Antineoplastic Agents
Cell Line
Cell Line
Tumor
medicine
Humans
Protein Kinase Inhibitors
Gene
Cell Proliferation
Hepatology
medicine.disease
APC
Triazines/pharmacology
Genes
Drug Resistance
Neoplasm
Cell culture
Protein Kinase Inhibitors/pharmacology
Cancer research
biology.protein
Zdroj: Gastroenterology, 157(4), 1153-1155.e1. W.B. Saunders Ltd
ISSN: 0016-5085
Databáze: OpenAIRE
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