Acute Basophilic Leukemia Arising from Chronic Myeloid Leukemia with Isolated Thrombocytosis
| Autor: | Xiliang Chen, Ting Li, Yun Zhang, Xiaosu Kang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ABL
Thrombocytosis business.industry Myelodysplastic syndromes Acute basophilic leukemia Chronic myeloid leukemia Myeloid leukemia Chromosomal translocation Hematology medicine.disease Leukemia hemic and lymphatic diseases medicine Cancer research Leukocytosis medicine.symptom business Letters to the Editor neoplasms Isolated thrombocytosis |
| Zdroj: | Turkish Journal of Hematology |
| ISSN: | 1308-5263 1300-7777 |
| Popis: | Acute basophilic leukemia (ABL) is a very uncommon form of acute myeloid leukemia (AML), accounting for 4-5% of all cases of acute non-lymphocytic leukemia. Most cases have been described to evolve from other hematological diseases, such as chronic myeloid leukemia (CML) and myelodysplastic syndromes (MDS). CML is one of the classical types of myeloproliferative neoplasms (MPN), characterized by the existence of a reciprocal translocation between the chromosomes 9 and 22, t(9;22)(q34:q11), resulting in BCR-ABL1 fusion gene. The peripheral blood routine typically manifests with leukocytosis, but rarely with isolated marked thrombocytosis. Here, we report a rare case of ABL transformed from CML with isolated significant thrombocytosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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