Muscle Satellite Cells and Endothelial Cells: Close Neighbors and Privileged Partners
| Autor: | Christo Christov, Fabrice Chrétien, Yann Bassaglia, Romain K. Gherardi, Vasily Shinin, Bénédicte Chazaud, Grégoire Vallet, Rana Abou-Khalil, Shahragim Tajbakhsh, Guillaume Bassez, François-Jérôme Authier |
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| Přispěvatelé: | Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Plateforme imagerie (PICTURES), IFR10, Cellules Souches et Développement, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Guellaen, Georges |
| Rok vydání: | 2007 |
| Předmět: |
Cellular differentiation
Muscle Fibers Skeletal Mice chemistry.chemical_compound 0302 clinical medicine Myocyte Muscular dystrophy Cells Cultured satellite cells 0303 health sciences Cell Differentiation Articles Anatomy Middle Aged endothelial cells Cell biology Endothelial stem cell medicine.anatomical_structure Intercellular Signaling Peptides and Proteins MYF5 Bromodeoxyuridine Adult Satellite Cells Skeletal Muscle Endothelium Neovascularization Physiologic [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology 03 medical and health sciences Dogs medicine Animals Humans stem cell niche Muscle Skeletal [SDV.BC] Life Sciences [q-bio]/Cellular Biology Molecular Biology Aged Cell Proliferation 030304 developmental biology Cell growth Cell Biology medicine.disease Mice Mutant Strains Capillaries Rats Mice Inbred C57BL Muscular Dystrophy Duchenne chemistry Endothelium Vascular 030217 neurology & neurosurgery |
| Zdroj: | Molecular Biology of the Cell Molecular Biology of the Cell, American Society for Cell Biology, 2007, 18 (4), pp.1397-1409. ⟨10.1091/mbc.E06-08-0693⟩ Molecular Biology of the Cell, 2007, 18 (4), pp.1397-1409. ⟨10.1091/mbc.E06-08-0693⟩ |
| ISSN: | 1939-4586 1059-1524 |
| DOI: | 10.1091/mbc.e06-08-0693 |
| Popis: | Genetically engineered mice (Myf5nLacZ/+, Myf5GFP-P/+) allowing direct muscle satellite cell (SC) visualization indicate that, in addition to being located beneath myofiber basal laminae, SCs are strikingly close to capillaries. After GFP+ bone marrow transplantation, blood-borne cells occupying SC niches previously depleted by irradiation were similarly detected near vessels, thereby corroborating the anatomical stability of juxtavascular SC niches. Bromodeoxyuridine pulse-chase experiments also localize quiescent and less quiescent SCs near vessels. SCs, and to a lesser extent myonuclei, were nonrandomly associated with capillaries in humans. Significantly, they were correlated with capillarization of myofibers, regardless to their type, in normal muscle. They also varied in paradigmatic physiological and pathological situations associated with variations of capillary density, including amyopathic dermatomyositis, a unique condition in which muscle capillary loss occurs without myofiber damage, and in athletes in whom capillaries increase in number. Endothelial cell (EC) cultures specifically enhanced SC growth, through IGF-1, HGF, bFGF, PDGF-BB, and VEGF, and, accordingly, cycling SCs remained mainly juxtavascular. Conversely, differentiating myogenic cells were both proangiogenic in vitro and spatiotemporally associated with neoangiogenesis in muscular dystrophy. Thus, SCs are largely juxtavascular and reciprocally interact with ECs during differentiation to support angio-myogenesis. |
| Databáze: | OpenAIRE |
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