Human Diurnal Preference and Circadian Rhythmicity Are Not Associated with the CLOCK 3111C/T Gene Polymorphism
| Autor: | David J. Klements, Anne Marie Chang, Alison M. Buch, Dayna S. Bradstreet, Jeanne F. Duffy |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Period (gene) CLOCK Proteins Poison control Biology Polymorphism Single Nucleotide Article Young Adult Polymorphism (computer science) Physiology (medical) Internal medicine medicine Humans Prospective Studies Circadian rhythm Allele Aged Melatonin Genetic association Chronotype Middle Aged Circadian Rhythm Endocrinology Female Gene polymorphism Sleep |
| Zdroj: | Journal of Biological Rhythms. 26:276-279 |
| ISSN: | 1552-4531 0748-7304 |
| DOI: | 10.1177/0748730411402026 |
| Popis: | Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker. |
| Databáze: | OpenAIRE |
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