Predictive Values of β-Trace Protein (Prostaglandin D Synthase) by Use of Laser-Nephelometry Assay for the Identification of Cerebrospinal Fluid

Autor: Bachmann, Gregor, Petereit, Hela, Djenabi, Uta, Michel, Olaf, Milhorat, Thomas H., Hodge, Charles J., Gjerris, Flemming, Olsen, Niels Vidiendal
Přispěvatelé: Ear, nose & throat
Rok vydání: 2002
Předmět:
Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Cerebrospinal Fluid Rhinorrhea
Clinical Neurology
Sensitivity and Specificity
cerebrospinal fluid
Prostaglandin-D synthase
Cerebrospinal fluid
Nephelometry and Turbidimetry
Predictive Value of Tests
Prostaglandin H D isomerase
Humans
Medicine
β-Trace protein
False Positive Reactions
Child
Aged
Retrospective Studies
Aged
80 and over
Laser nephelometry
rhinorrhea
medicine.diagnostic_test
biology
Cerebrospinal Fluid Otorrhea
business.industry
Lasers
Magnetic resonance imaging
Middle Aged
Predictive value
Lipocalins
Intramolecular Oxidoreductases
Glucose
Paranasal sinuses
medicine.anatomical_structure
Child
Preschool
biology.protein
protein isoforms
Surgery
Neurology (clinical)
medicine.symptom
β-Globulins
business
Nuclear medicine
Nephelometry
Zdroj: Neurosurgery. 50:571-577
ISSN: 0148-396X
Popis: OBJECTIVE beta-Trace protein (beta-TP) is an immunological marker for the detection of cerebrospinal fluid traces. The aim of the study was to evaluate the predictive values of a new research assay for beta-TP. METHODS A total of 154 specimens from patients with otorrhea or rhinorrhea were investigated for cerebrospinal fluid (CSF) by use of a laser-nephelometric assay for beta-TP. Samples were obtained between January 1994 and November 2000. A sample was reported to be positive for CSF when the beta-TP concentration was more than 6 mg/L. Case evaluations were performed retrospectively and tabulated for indication, clinical course, additional investigations, surgical procedure, and follow-up. RESULTS beta-TP was detected in 16 specimens; 138 samples were negative for beta-TP with a value less than 3 mg/L. One sample was suggestive of CSF traces at 4.6 mg/L. In correlation with the clinical course, the intraoperative findings, intraoperative visualization with sodium fluorescein, high-resolution computed tomography of the paranasal sinuses or the petrous bone, computed tomographic cisternography, magnetic resonance imaging, and radionuclide cisternography, there was no false-positive result. On four occasions, false-negative results occurred, with an overall accuracy of 0.974. The beta-TP test had a negative predictive value of 0.971 and a positive predictive value of 1. CONCLUSION Analysis of betas-TP via the nephelometric assay is a valuable and reliable test in cranial base surgery for the identification of CSF.
Databáze: OpenAIRE
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