High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide predict mortality in stable coronary artery disease: results from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
| Autor: | Tanja B. Grammer, Winfried Koch, Andrea Horsch, Eberhard Spanuth, Evangelos Giannitsis, Wolfgang Koenig, Winfried März, Marcus E. Kleber |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Cardiac troponin Cardiovascular health Clinical Biochemistry Coronary Artery Disease Logistic regression Coronary artery disease Troponin T Internal medicine Natriuretic Peptide Brain medicine Risk of mortality Humans Survival analysis Aged Aged 80 and over Immunoassay business.industry Biochemistry (medical) General Medicine Middle Aged medicine.disease Prognosis Survival Analysis Peptide Fragments Logistic Models ROC Curve Risk stratification Cardiology Female business Biomarkers Follow-Up Studies |
| Zdroj: | Clinical chemistry and laboratory medicine. 51(10) |
| ISSN: | 1437-4331 |
| Popis: | Background: The simultaneous assessment of high-sensitivity cardiac troponin T (hscTnT) and NT-proBNP for predicting death in stable coronary artery disease (CAD) has yet not been examined. We investigated the additional contribution of hscTnT to the risk of mortality prediction of NT-proBNP in patients with stable CAD. Methods: We studied 1469 patients with stable CAD enrolled in the Ludwigshafen Risk and Cardiovascular Health Study (LURIC). hscTnT and NT-proBNP were measured in baseline samples using immunoassays (Roche Diagnostics, Germany). Results: Thirty-five percent (n=525) of the patients died during a median follow-up of 7 and a half years. In total 59.0% of the non-survivors and 25.2% of the survivors exhibited concentrations of hscTnT≥14 ng/L. Logistic regression analysis identified hscTnT and NT-proBNP as independent risk markers for short-term (1-year follow-up) and long-term (9-years follow-up) mortality. ROC curve analysis determined optimal univariate cut-offs at 14 ng/L and 443 µg/L for hscTnT (AUC 0.725, p Conclusions: The majority of non-survivors exhibited increased hscTnT concentrations above 14 ng/L. The simultaneous determination of NT-proBNP and hscTnT was superior for risk stratification compared to determining either marker alone. Especially the prediction of the clinically important 1-year mortality was significantly improved by addition of hscTnT to NT-proBNP. |
| Databáze: | OpenAIRE |
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