Cutting Edge: In the Absence of Regulatory T Cells, a Unique Th Cell Population Expands and Leads to a Loss of B Cell Anergy
| Autor: | Stephen B. Gauld, Steven M. Leonardo, Jessica L. De Santis, Laurent Malherbe |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
CD4-Positive T-Lymphocytes
B-cell anergy Immunology Cell Population B-Lymphocyte Subsets Clonal Deletion Mice Transgenic Biology medicine.disease_cause T-Lymphocytes Regulatory Autoimmunity Mice medicine Animals Immunology and Allergy Cell Lineage B-cell activating factor education Cells Cultured B cell Clonal Anergy education.field_of_study Germinal center Cell Differentiation Immune dysregulation Coculture Techniques Mice Inbred C57BL medicine.anatomical_structure |
| Zdroj: | The Journal of Immunology. 188:5223-5226 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1103731 |
| Popis: | The absence of regulatory T cells (Tregs) results in significant immune dysregulation that includes autoimmunity. The mechanism(s) by which Tregs suppress autoimmunity remains unclear. We have shown that B cell anergy, a major mechanism of B cell tolerance, is broken in the absence of Tregs. In this study, we identify a unique subpopulation of CD4+ Th cells that are highly supportive of Ab production and promote loss of B cell anergy. Notably, this novel T cell subset was shown to express the germinal center Ag GL7 and message for the B cell survival factor BAFF, yet failed to express markers of the follicular Th cell lineage. We propose that the absence of Tregs results in the expansion of a unique nonfollicular Th subset of helper CD4+ T cells that plays a pathogenic role in autoantibody production. |
| Databáze: | OpenAIRE |
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