Markers of apoptosis in stage IB squamous cervical carcinoma
| Autor: | Ruth Holm, A. K. Lie, Gunnar B. Kristensen, G. van de Putte, Mark Baekelandt |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Oncology Cytoplasm Pathology medicine.medical_specialty medicine.medical_treatment bcl-X Protein Uterine Cervical Neoplasms Apoptosis Biology Pathology and Forensic Medicine Immunoenzyme Techniques Bcl-2-associated X protein Internal medicine Biomarkers Tumor medicine Humans Neoplasm Invasiveness Radical Hysterectomy Neoplasm Staging Retrospective Studies bcl-2-Associated X Protein Cervical cancer Hysterectomy Uterine prolapse Original Articles General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Neoplasm Proteins stomatognathic diseases Proto-Oncogene Proteins c-bcl-2 Epidermoid carcinoma Carcinoma Squamous Cell biology.protein Immunohistochemistry Female Lymphadenectomy |
| Zdroj: | Journal of Clinical Pathology. 58:590-594 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.2004.021220 |
| Popis: | To examine the prognostic relevance of the expression of the Bcl-2, Bcl-xL, and Bax proteins in stage IB squamous cervical carcinoma (SCC).In total, 220 patients who underwent radical hysterectomy and bilateral lymphadenectomy at the Norwegian Radium Hospital for stage IB SCC between 1987 and 1993 were studied. Immunohistochemistry using monoclonal antibodies against Bcl-2, Bcl-xL, and Bax was used to examine protein expression. Ten patients who underwent hysterectomy for uterine prolapse served as controls.Cytoplasmic expression of Bcl-2, Bcl-xL, and Bax was low (5% positive cells) in 159 of 220 (73%), 193 of 220 (87%), and 39 of 220 (18%) tumours, respectively, and high (or = 5% positive cells) in 61 of 220 (27%), 27 of 220 (13%), and 181 of 220 (82%) tumours, respectively. In univariate analysis, all classic clinicopathological parameters but none of the investigated proteins were associated with prognosis. In multivariate analysis, only deep stromal invasion was independently related to survival.Bcl-2, Bcl-xL, and Bax were not independently associated with prognosis in stage IB SCC. |
| Databáze: | OpenAIRE |
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