Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts
| Autor: | Anna Maria Testi, Daniela Silvestri, Geertruy te Kronnie, Franco Mandelli, Francesca Mancini, Felicetto Ferrara, Francesco Fabbiano, Robin Foà, Giovanni Cazzaniga, Sonia Maria Orlando, Sabina Chiaretti, Anna Guarini, Antonella Vitale, Giuseppe Fioritoni, Giorgina Specchia, Giovanni Pizzolo, Giuseppe Basso, Alessandra Tedeschi, Giovanna Meloni, Francesco Di Raimondo, Andrea Biondi, Loredana Elia, Paola Fazi, Maria Grazia Valsecchi, Valentino Conter |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Immunophenotyping hemic and lymphatic diseases medicine Humans Young adult Child Retrospective Studies business.industry Incidence (epidemiology) Age Factors Infant Retrospective cohort study Articles Hematology Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease 3. Good health Leukemia Italy Child Preschool 030220 oncology & carcinogenesis Cohort Adult Acute Lymphoblastic Leukemia Female business 030215 immunology Cohort study |
| Zdroj: | Haematologica; Vol 98 |
| ISSN: | 1592-8721 0390-6078 |
| Popis: | The outcome of children and adults with acute lymphoblastic leukemia is markedly different. Since there is limited information on the distribution of clinico-biological variables in different age cohorts, we analyzed 5202 patients with acute lymphoblastic leukemia enrolled in the Italian multicenter AIEOP and GIMEMA protocols and stratified them in nine age cohorts. The highest prevalence of acute lymphoblastic leukemia was observed in children, although a second peak was recorded from the 4(th) decade onwards. Interestingly, the lowest incidence was found in females between 14-40 years. Immunophenotypic characterization showed a B-lineage in 85.8% of patients: a pro-B stage, associated with MLL/AF4 positivity, was more frequent in patients between 10-50 years. T-lineage leukemia (14.2%) was rare among small children and increased in patients aged 10-40 years. The prevalence of the BCR/ABL1 rearrangement increased progressively with age starting from the cohort of patients 10-14 years old and was present in 52.7% of cases in the 6th decade. Similarly, the MLL/AF4 rearrangement constantly increased up to the 5(th) decade, while the ETV6/RUNX1 rearrangement disappeared from the age of 30 onwards. This study shows that acute lymphoblastic leukemia in adolescents and young adults is characterized by a male prevalence, higher percentage of T-lineage cases, an increase of poor prognostic molecular markers with aging compared to cases in children, and conclusively quantified the progressive increase of BCR/ABL(+) cases with age, which are potentially manageable by targeted therapies. |
| Databáze: | OpenAIRE |
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