Primary Episcleral Melanoma Consistent with Uveal Melanoma Mutations Treated by Excision and Gamma Knife Stereotactic Radiosurgery
| Autor: | Marc L. Otten, Eileen Chang, Spencer T. Langevin, Brian P. Marr, Israel Deutsch, Tony J. C. Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
PRAME business.industry medicine.medical_treatment Molecular genetic testing Melanoma Cryotherapy Gamma knife medicine.disease eye diseases Radiosurgery Ocular melanocytosis Stereotactic radiotherapy 03 medical and health sciences 0302 clinical medicine Novel Insights from Clinical Practice 030220 oncology & carcinogenesis 030221 ophthalmology & optometry Medicine sense organs Radiology business General Nursing |
| Zdroj: | Ocul Oncol Pathol |
| ISSN: | 2296-4657 2296-4681 |
| DOI: | 10.1159/000502309 |
| Popis: | Ocular melanocytosis has traditionally been associated with increased risk of developing uveal melanoma; however, rarely primary episcleral melanoma has been reported in the literature. Herein, we present the third case of primary episcleral melanoma treated by complete excision and cryotherapy. In contrast to previous cases, we obtained molecular genetic testing which revealed a GNA-11 mutation, and gene expression profiling resulted in a Class 2 PRAME positive tumor diagnosis. These two tests which have never been performed on previous cases, support lineage similar to uveal melanoma. In addition, we are the first case to report treatment of the surgical bed and surrounding orbital tissue with Gamma Knife stereotactic radiotherapy to both treat residual tissue and decrease risk of recurrence. |
| Databáze: | OpenAIRE |
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