The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder
| Autor: | Sandra Odebrecht Vargas Nunes, Décio Sabbatini Barbosa, Elisa Brietzke, Lucas B. Rizzo, Pawan Kumar Maurya, Maiara Zeni, Michael Maes, Sumit Sethi, Rodrigo B. Mansur, Adiel C. Rios, Cristiano Noto |
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| Rok vydání: | 2016 |
| Předmět: |
Aging
medicine.medical_specialty Oxidative phosphorylation medicine.disease_cause behavioral disciplines and activities Proinflammatory cytokine Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine mental disorders medicine Animals Humans Psychiatry Biological Psychiatry Pharmacology Coenzyme Q10 Depressive Disorder Major Glutathione medicine.disease PON1 030227 psychiatry Oxidative Stress Endocrinology chemistry Major depressive disorder Psychology Biomarkers 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 65:134-144 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2015.08.016 |
| Popis: | Major depressive disorder (MDD) affects millions of individuals and is highly comorbid with many age associated diseases such as diabetes mellitus, immune-inflammatory dysregulation and cardiovascular diseases. Oxidative/nitrosative stress plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative/neuropsychiatric disorders including MDD. In this review, we critically review the evidence for an involvement of oxidative/nitrosative stress in acceleration of aging process in MDD. There are evidence of the association between MDD and changes in molecular mechanisms involved in aging. There is a significant association between telomere length, enzymatic antioxidant activities (SOD, CAT, GPx), glutathione (GSH), lipid peroxidation (MDA), nuclear factor κB, inflammatory cytokines with MDD. Major depression also is characterized by significantly lower concentration of antioxidants (zinc, coenzyme Q10, PON1). Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising. |
| Databáze: | OpenAIRE |
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