HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a
| Autor: | Sajida Hassan, Humera Kausar, Fouzia T Javed, Imran Shahid, Sana Gull, Sultan Asad, Bushra Ijaz, Muhammad Sarwar, Waqar Ahmad |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male Adolescent Genotype Cross-sectional study Hepacivirus Severity of Illness Index lcsh:Infectious and parasitic diseases Young Adult Virology medicine Humans lcsh:RC109-216 Prospective Studies Prospective cohort study Aged biology Receiver operating characteristic business.industry Research Area under the curve Hepatitis C Middle Aged Viral Load medicine.disease biology.organism_classification Prognosis Cross-Sectional Studies Treatment Outcome Infectious Diseases Liver Immunology Female business Viral load Biomarkers |
| Zdroj: | Virology Journal Virology Journal, Vol 8, Iss 1, p 293 (2011) |
| ISSN: | 1743-422X |
| DOI: | 10.1186/1743-422x-8-293 |
| Popis: | Background Several factors have been proposed to assess the clinical outcome of HCV infection. The correlation of HCV genotypes to possible serum markers in clinical prediction is still controversial. The main objective of this study was to determine the existence of any correlation between HCV genotypes to viral load and different clinical serum markers. Methods We performed a prospective cross-sectional and observational study. About 3160 serum HCV RNA positive patients were chosen from 4020 randomly selected anti-HCV positive patients. Statistical analysis was performed using the SPSS 16 software package. ROC (receiver operating characteristics) curves were used to compare diagnostic values of serum markers to predict genotypes. Results The most prevalent genotype was 3a (73.9%) followed by 1a (10.7%), 4a (6.4%) and 3b (6.1%) in Pakistani population. No correlation was found between viral load and serum markers for genotype 3a in a large no. of sample (n = 2336). While significant correlation was observed between viral load and AST in genotype 3b, ALP with viral load and ALT for genotype 1a. Patients with genotype 4a showed a significant inverse correlation with viral load and Hb level and AST with ALP. For genotype 4a, AUC (area under the curve) of ALT, ALP, AST, bilirubin, Hb level and viral load was 0.790, 0.763, 0.454, 0.664, 0.458 and 0.872 respectively. Conclusions In conclusion, there was a significant variable response of HCV genotypes with serum markers. Severity of disease is independent of serum marker level in genotype 3a, while the liver damage in genotype 4a may associate with viral cytopathic effect as well as the immune-mediated process. An index using six serum markers may correctly predict genotype 4a in patients with ≥75% accuracy. |
| Databáze: | OpenAIRE |
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