Differences in Monocyte Subsets and Monocyte-Platelet Aggregates in Acute Myocardial Infarction-PreliminaryResults
| Autor: | Kamil Grubczak, Paula Miklasz, Halina Kemona, Olga M. Koper-Lenkiewicz, Joanna Kamińska, Paweł Kiszło, Anna Lisowska, Violetta Dymicka-Piekarska, Marcin Moniuszko |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Adolescent Platelet Aggregation 030204 cardiovascular system & hematology Stable angina Monocytes 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans In patient Platelet cardiovascular diseases 030212 general & internal medicine Myocardial infarction Angina Stable Non-ST Elevated Myocardial Infarction Aged Monocyte subsets business.industry Monocyte General Medicine Middle Aged medicine.disease medicine.anatomical_structure Cardiology ST Elevation Myocardial Infarction Female business |
| Zdroj: | The American journal of the medical sciences. 357(5) |
| ISSN: | 1538-2990 |
| Popis: | Background Monocyte-platelet interaction may favor the development of a proatherogenic monocyte phenotype. It is still uncertain which of the 3 monocyte subpopulations interact with platelets to form monocyte-platelet aggregates (MPAs) in acute myocardial infarctions. The aim of our study was to evaluate the monocyte subsets, the percentage of MPAs and the involvement of monocyte subsets in MPA formation among patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI), and compared to patients with stable angina (SA). Methods Monocyte subsets and MPAs formation were measured in blood collected in 3.2% sodium citrate tubes by means of flow cytometry. Results Classical, intermediate and nonclassical monocyte percentages were statistically different when comparing patients with STEMI and NSTEMI. Moreover, classical and intermediate monocytes were statistically different when comparing the STEMI and SA group; however, only the classical monocyte subset was found to be higher in the acute myocardial infarction group compared to the SA group. The percentage of MPAs was significantly higher in STEMI (50.1%) compared to NSTEMI (22.9%). We found no differences in the involvement of monocyte subsets in MPA formation between patients with STEMI and NSTEMI and in comparison with the SA group. Conclusions These findings suggest that the increase in circulating levels of classical monocytes in patients with STEMI as compared to NSTEMI reflects the severity of the acute event. The increased percentage of MPAs may favor the development of STEMI compared to NSTEMI. |
| Databáze: | OpenAIRE |
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