Anti-androgenic and hair growth promoting activities of Lygodii spora (spore of Lygodium japonicum) I. Active constituents inhibiting testosterone 5alpha-reductase
| Autor: | Hideaki Matsuda, Yusuke Asanuma, Miho Yamazaki, Shunsuke Naruto, Michinori Kubo |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Spores Linoleic acid Pharmaceutical Science Biology Reductase Pharmacognosy Pharmacology Palmitic acid chemistry.chemical_compound Mice 5-alpha Reductase Inhibitors Cricetinae Animals Nandrolone Testosterone Enzyme Inhibitors Lygodium japonicum Fatty Acids Biological activity Androgen Antagonists General Medicine biology.organism_classification Spore Mice Inbred C57BL chemistry Biochemistry Ferns Hair |
| Zdroj: | Biologicalpharmaceutical bulletin. 25(5) |
| ISSN: | 0918-6158 |
| Popis: | The aqueous ethanol extract of Lygodii Spora (spore of Lygodium japonicum (Thunb.) Sw.) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. From the lipophilic constituents of Lygodii Spora, oleic, linoleic and palmitic acids were identified as the main active principles inhibiting testosterone 5alpha-reductase. |
| Databáze: | OpenAIRE |
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