Comparison of the Acinetobacter baumannii Reference Strains ATCC 17978 and ATCC 19606 in Antimicrobial Resistance Mediated by the AdeABC Efflux Pump
| Autor: | Paul G. Higgins, Stefanie Gerson, Julia Wille, Thorsten Wille, Kyriaki Xanthopoulou, Harald Seifert, Kai Lucaßen |
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| Rok vydání: | 2021 |
| Předmět: |
Acinetobacter baumannii
Pharmacology 0303 health sciences biology 030306 microbiology Chemistry Membrane Transport Proteins Amino acid substitution Microbial Sensitivity Tests Acinetobacter biology.organism_classification Anti-Bacterial Agents Microbiology 03 medical and health sciences Infectious Diseases Antibiotic resistance Bacterial Proteins Mechanisms of Resistance Drug Resistance Multiple Bacterial Drug Resistance Bacterial Pharmacology (medical) Efflux Differential expression 030304 developmental biology |
| Zdroj: | Antimicrob Agents Chemother |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | The Acinetobacter baumannii RND efflux pump AdeABC is regulated by the 2-component regulator AdeRS. In this study, we compared the regulation and expression of AdeABC of the reference strains ATCC 17978 and ATCC 19606. A clearly stronger efflux activity was demonstrated for ATCC 19606. An amino acid substitution at residue 172 of adeS was identified as a potential cause for differential expression of the pump. Therefore, we recommend caution with exclusively using single reference strains for research. |
| Databáze: | OpenAIRE |
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