Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy
| Autor: | Inn-Chi Lee, Da-Yang Chen, Xing-An Wang, Swee-Hee Wong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) Clinical Biochemistry education.educational_degree Encephalopathy Stage ii Gastroenterology Habilitation Article R5-920 newborn Internal medicine medicine In patient Stage (cooking) education HIE neurodevelopment business.industry Odds ratio hearing impairment medicine.disease Neonatal Hypoxic Ischemic Encephalopathy Biomarker (medicine) biomarker business |
| Zdroj: | Diagnostics, Vol 11, Iss 2056, p 2056 (2021) Diagnostics Volume 11 Issue 11 |
| ISSN: | 2075-4418 |
| Popis: | Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic–ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared those patients with 11,837 newborns without HIE, and analyzed the risk factors of HIs among neonatal HIE. Of the 78 patients, 11 were confirmed to have an HI, which is a substantially higher percentage than in the 11,837 newborns without HIE (14.1% vs. 0.87% p < 0.001). More patients with moderate-to-severe HIE had confirmed HIs (p = 0.020 odds ratio, 8.61) than those with mild HIE. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE. The patients who exhibited HIs had significantly higher lactate (104.8 ± 51.0 vs. 71.4 ± 48.4 U = 181, p = 0.032) and serum glucose (159.5 ± 86.1 vs. 112.1 ± 62.3 U = 166, p = 0.036) levels than those without HIs. A higher prevalence of HIs was noted in the patients with stage III HIE than those with stage II HIE (43.8% vs. 10% p = 0.008). The degree of HI correlated with brain anomalies and neurodevelopmental outcomes at 1 year of age. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE. |
| Databáze: | OpenAIRE |
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