NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis
| Autor: | Yasuhiro Indo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pain Insensitivity Congenital Receptor tyrosine kinase for NGF Emotions Tropomyosin receptor kinase A Receptor tyrosine kinase Interoception Behavioral Neuroscience 0302 clinical medicine Congenital insensitivity to pain with anhidrosis Neurotrophic factors Nerve Growth Factor Homeostasis NTRK1 gene Medicine Neurons biology Genetic disorder Brain NTRK1 Gene TrkA receptor Neuropsychology and Physiological Psychology medicine.anatomical_structure Allostasis Nerve growth factor (NGF) Peripheral nervous system Sympathetic postganglionic neurons Cognitive Neuroscience Stress 03 medical and health sciences Feeling Peripheral Nervous System Animals Humans Receptor trkA 491.17 Emotion Inflammation Hypohidrosis NGF-dependent neurons business.industry medicine.disease 030104 developmental biology Nerve growth factor nervous system biology.protein NGF-dependent primary afferent neurons business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and biobehavioral reviews. 87 |
| ISSN: | 1873-7528 |
| Popis: | NGF is a well-studied neurotrophic factor, and TrkA is a receptor tyrosine kinase for NGF. The NGF-TrkA system supports the survival and maintenance of NGF-dependent neurons during development. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder due to loss-of-function mutations in the NTRK1 gene encoding TrkA. Individuals with CIPA lack NGF-dependent neurons, including NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise intact systems. Thus, the pathophysiology of CIPA can provide intriguing findings to elucidate the unique functions that NGF-dependent neurons serve in humans, which might be difficult to evaluate in animal studies. Preceding studies have shown that the NGF-TrkA system plays critical roles in pain, itching and inflammation. This review focuses on the clinical and neurobiological aspects of CIPA and explains that NGF-dependent neurons in the peripheral nervous system play pivotal roles in interoception and homeostasis of our body, as well as in the stress response. Furthermore, these NGF-dependent neurons are likely requisite for neurobiological processes of 'emotions and feelings' in our species. |
| Databáze: | OpenAIRE |
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