High-Fat Diet-Induced Alterations in the Feeding Suppression of Low-Dose Nisoxetine, a Selective Norepinephrine Reuptake Inhibitor
| Autor: | Amy L. Walters, Priscila P. Cunha, Nicholas T. Bello, Jessica L. Verpeut |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
lcsh:Internal medicine medicine.medical_specialty Article Subject Endocrinology Diabetes and Metabolism medicine.medical_treatment Blood Pressure Diet High-Fat Weight Gain Rats Sprague-Dawley Norepinephrine (medication) Eating Norepinephrine Heart Rate Fluoxetine Internal medicine Heart rate medicine Animals lcsh:RC31-1245 Saline Dose-Response Relationship Drug Appetite Regulation business.industry Arcuate Nucleus of Hypothalamus Nisoxetine Immunohistochemistry Rats Endocrinology Blood pressure Hypothalamus medicine.symptom business Proto-Oncogene Proteins c-fos Weight gain Research Article medicine.drug |
| Zdroj: | Journal of Obesity Journal of Obesity, Vol 2013 (2013) |
| ISSN: | 2090-0708 |
| DOI: | 10.1155/2013/457047 |
| Popis: | Central noradrenergic pathways are involved in feeding and cardiovascular control, physiological processes altered by obesity. The present studies determined how high-fat feeding and body weight gain alter the sensitivity to the feeding suppression and neural activation to a selective norepinephrine reuptake inhibitor, nisoxetine. Acute administration of nisoxetine (saline: 0, 3, 10, and 30 mg/kg; IP) resulted in a dose-dependent reduction in the 24 h refeeding response in male Sprague Dawley rats maintained on standard chow. In a similar fashion, nisoxetine resulted in reductions in blood pressure and a compensatory increase in heart rate. From these studies, the 3 mg/kg dose was subthreshold. In a separate experiment, however, 10 wk exposure to a high-fat diet (60% fat) resulted in weight gain and significant feeding suppression following administration of nisoxetine (3 mg/kg) compared with animals fed a control diet (10% fat). Nisoxetine (3 mg/kg) also resulted in greater neural activation, as measured by c-Fos immunohistochemistry, in the arcuate nucleus of the hypothalamus in animals exposed to the high-fat diet. Such data indicate acute nisoxetine doses that suppress food intake can impact cardiovascular measures. It also suggests that the feeding suppression to a low-dose nisoxetine is enhanced as a result of high-fat diet and weight gain. |
| Databáze: | OpenAIRE |
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