Exportin T and Exportin 5: tRNA and miRNA biogenesis – and beyond
| Autor: | Matthias S. Leisegang, Markus T. Bohnsack, Ana S. Ramírez, Roman Martin |
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| Rok vydání: | 2012 |
| Předmět: |
0303 health sciences
gene expression nuclear export ribosome RNA transport RNP biogenesis translation Clinical Biochemistry RNA In Vitro Techniques Karyopherins Biology Biochemistry Ribosome Cell biology MicroRNAs 03 medical and health sciences 0302 clinical medicine RNA Transfer Nucleocytoplasmic Transport 030220 oncology & carcinogenesis Gene expression Transfer RNA Humans Nuclear transport Nuclear export signal Molecular Biology Biogenesis 030304 developmental biology |
| Zdroj: | bchm. 393:599-604 |
| ISSN: | 1437-4315 1431-6730 |
| DOI: | 10.1515/hsz-2012-0146 |
| Popis: | The biogenesis of most eukaryotic kinds of RNA requires nuclear export, which is mediated by a variety of specific nuclear transport receptors. The nuclear export receptors Exportin-t (Exp-t) and Exportin 5 (Exp5), and their homologues, are involved in the export of transfer RNA to the cytoplasm. Exp5 is further involved in additional nucleocytoplasmic transport pathways, which include nuclear export of microRNA precursors (pre-miRNAs) and pre-60S ribosomal subunits. Inactivation of Exp5 results in nuclear accumulation of pre-miRNAs and perturbation of gene expression, and its mutation was recently found in malignant diseases. Here, we compare the cellular function of Exp5 and Exp-t with focus on Exp5 substrates and its role in diseases. |
| Databáze: | OpenAIRE |
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