Early detection of right ventricular diastolic dysfunction by pulsed tissue Doppler echocardiography in iron loaded beta thalassemia patients
| Autor: | Amal El-Beshlawy, Fatma Alzahraah, Hala Agha, Mona Eltagui, Osama Abdelaziz, Alaa A. Sobeih, Mona Hamdy, Antoine Fakhry AbdelMassih, Fadwa Said, Pennell J. Dudley, Inas Abdelsattar |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Hemosiderosis Adolescent Thalassemia Immunology Diastole Doppler echocardiography Biochemistry Doppler imaging Asymptomatic Young Adult Tissue Doppler echocardiography Internal medicine medicine Humans cardiovascular diseases Child Echocardiography Doppler Pulsed medicine.diagnostic_test business.industry beta-Thalassemia Beta thalassemia Magnetic resonance imaging Cell Biology Hematology medicine.disease Magnetic Resonance Imaging Case-Control Studies Pediatrics Perinatology and Child Health Ferritins cardiovascular system Cardiology Ventricular Function Right Female Siderosis medicine.symptom Cardiology and Cardiovascular Medicine business Cardiomyopathies |
| Zdroj: | Pediatric cardiology. 36(3) |
| ISSN: | 1432-1971 |
| Popis: | Introduction Iron overload contributes to cardiac dysfunction in patients with beta thalassemia. Early heart iron overload can be quantified through cardiovascular magnetic resonance (CMR) T2*. Objective to clarify the value of tissue Doppler imaging (TDI) in early detection of global myocardial dysfunction in iron loaded thalassemia major patients diagnosed by CMR. Patients and Methods Two groups were included in the study; Group I: 69 asymptomatic thalassemia patients (28 females, 41 males), mean age 18.1±7.03 years (range 6 to 39 years), Group II (n=41) healthy normal controls matched for age and sex. Serum ferritin and CMR were performed to assess the degree of cardiac siderosis (T2*< 20 ms). Group I was subdivided into two subgroups; Group Ia (n=26) T2*20ms. Conventional echocardiography and Doppler of LV, RV dimensions and functions and pulmonary artery pressure were evaluated. TDI measures included systolic and diastolic myocardial velocities (S', E', A' and E'/A') of the basal segments of septal, lateral LV and RV free walls. Results Right ventricular diastolic function assessed by tricuspid annular E'/A' was positively correlated with T2* value; the lower tricuspid E'/A' ratio the lower T2* value (r = +0.366, P=0.002). Tricuspid annular A' was significantly higher in group Ia compared to group Ib (16.7 ±5.2cm/s versus 12.1 ±4.0cm/s, P20ms) (6,357±2478 microgram/L versus 2,965±2289 microgram/L (P Conclusion Pulsed tissue Doppler imaging (TDI) is a promising tool for quantitative assessment of myocardial function and early detection of right ventricular diastolic dysfunction in iron loaded beta thalassemia major patients assessed by cardiovascular magnetic resonance. Disclosures: No relevant conflicts of interest to declare. |
| Databáze: | OpenAIRE |
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