Cytokine receptor profile of arthroplasty macrophages, foreign body giant cells and mature osteoclasts
| Autor: | S D Neale, Nicholas A. Athanasou |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Giant Cells Foreign-Body Reoperation Macrophage colony-stimulating factor Pathology medicine.medical_specialty Foreign-body giant cell Osteolysis Knee Joint Joint Prosthesis medicine.medical_treatment Osteoclasts Bone Neoplasms Immunophenotyping Immune system Osteoclast medicine Humans Macrophage Receptors Growth Factor Orthopedics and Sports Medicine Receptors Cytokine Aged Giant Cell Tumor of Bone business.industry Macrophages Cell Differentiation Middle Aged medicine.disease Immunohistochemistry Prosthesis Failure Equipment Failure Analysis Cytokine medicine.anatomical_structure Female Hip Joint Surgery Cytokine receptor business Joint Capsule |
| Zdroj: | Acta Orthopaedica Scandinavica. 70:452-458 |
| ISSN: | 0001-6470 |
| DOI: | 10.3109/17453679909000980 |
| Popis: | In the arthroplasty pseudomembrane surrounding a loose prosthesis there is a marked macrophage and foreign body giant cell (FBGC) response to implant-derived wear particles. These cells contribute to the osteolysis of loosening by releasing cytokines and growth factors which influence the formation and activity of osteoclasts. Using a panel of monoclonal antibodies directed against known cytokine/growth factor receptors, we have determined by immunohistochemistry whether arthroplasty macrophages, FB-GCs and osteoclasts express receptors for cytokines and growth factors that are known to modulate osteolysis. All these cell types reacted with antibodies directed against the following cytokine/growth factor receptors: gp130, IL-1R type 1, IL-2R, IL-4R, IL-6R, TNFR, M-CSFR, GM-CSFR and SCFR but not with antibodies directed against IL-3R and IL-8R. Arthroplasty macrophages, FBGCs and osteoclasts thus show a similar pattern of cytokine/growth factor receptor expression. This reflects the fact that arthroplasty macrophages are capable of osteoclast differentiation and that these cell types form part of the mononuclear phagocyte system. As regards the osteolysis of aseptic loosening, it also indicates that these cells are targets for numerous cytokines and growth factors which influence osteoclast formation and bone resorption. |
| Databáze: | OpenAIRE |
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