Inspiratory contrast for in vivo optical imaging
| Autor: | Gregory W. Faris, Kenneth T. Kotz, Juan Orduna, Ashley D. Gibbs, Zishan A. Haroon, Sanhita Dixit, Khalid Amin |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
media_common.quotation_subject Contrast Media Mice Nude Cancer imaging Tumor vasculature Sensitivity and Specificity Mice Optics Optical imaging In vivo Neoplasms Administration Inhalation medicine Contrast (vision) Animals Medical physics Whole Body Imaging media_common medicine.diagnostic_test Chemistry business.industry Cancer Reproducibility of Results Carbon Dioxide medicine.disease Image Enhancement Atomic and Molecular Physics and Optics Oxygen Angiography business Preclinical imaging Biomedical engineering |
| Zdroj: | Optics express. 16(1) |
| ISSN: | 1094-4087 |
| Popis: | We demonstrate the use of inspired oxygen and carbon dioxide as a possible route to increase contrast in optical imaging of cancerous tissue. Differential imaging in human xenograft rodent models of cancer exhibits significant variation in signal between normal and cancerous tissue. This differential cancer-specific contrast is stronger and more consistent than the conventional static contrast. This differential technique exploits the response of abnormal tumor vasculature to inhaled gases and could provide a promising alternative to supplement mainstream cancer imaging modalities such as x-rays and MRI. |
| Databáze: | OpenAIRE |
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