Epidemic of Klebsiella pneumoniae ST11 Clone Coproducing KPC-2 and 16S rRNA Methylase RmtB in a Chinese University Hospital
| Autor: | Lanjuan Li, Jun-Jie Li, Hai-Feng Miao, Sheng Bi, Fei-Shu Hu, Zhongkang Ji, Zi-Ke Sheng, Jifang Sheng, Mei Deng |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male China Carbapenem Genotype Klebsiella pneumoniae Epidemic Microbial Sensitivity Tests Tigecycline Fosfomycin Polymerase Chain Reaction beta-Lactamases lcsh:Infectious and parasitic diseases Microbiology Cohort Studies Hospitals University rmtB medicine Humans lcsh:RC109-216 Aged Retrospective Studies Aminoglycoside biology Methyltransferases biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses biology.organism_classification Virology Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Klebsiella Infections Multiple drug resistance KPC Infectious Diseases Amikacin Colistin Multilocus sequence typing Female Research Article Multilocus Sequence Typing medicine.drug |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 12, Iss 1, p 373 (2012) |
| ISSN: | 1471-2334 |
| Popis: | Background Emergence of rmtB-positive Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) poses a great threat to antimicrobial treatment options. Methods From January 2010 to December 2010, non-duplicate KPC-KP isolates from our hospital were screened for rmtB and multiple other resistance determinants with PCR. Subsequent studies included MIC determination, PFGE, and multilocus sequence typing. Records from patients with KPC-KP isolated were retrospectively reviewed. Comparisons of molecular and clinical characteristics between rmtB-positive and rmtB–negative isolates were systematically performed, as well as the environmental colonization study in ICU wards. Results A total of 84 KPC-KP strains were collected, including 48 rmtB-positive KPC-KP (RPKP) and 36 rmtB-negative KPC-KP (RNKP) isolates. All KPC-KP isolates were multidrug resistant, with colistin and tigecycline being the most active agents. Compared with RNKP, RPKP displayed a much severer resistance phenotype. Susceptibility rates for amikacin (0% for RPKP versus 88.9% for RNKP, p p p Conclusions RPKP strains have spread widely and gradually replaced RNKP in our hospital. They seemed to show much severer resistance phenotypes compared with RNKP and had a bigger dissemination potential. Prudent use of available active agents combined with good control practices is therefore mandatory. |
| Databáze: | OpenAIRE |
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