The role of vitamin D in breast cancer
| Autor: | Sreenivasa R Chandana, Tu Tu Aung, Nikolay V. Dimitrov, Karl J. D’Silva |
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| Rok vydání: | 2009 |
| Předmět: |
Vitamin
lcsh:Internal medicine Cancer Research medicine.medical_specialty medicine.drug_class medicine.disease_cause vitamin D deficiency Metastasis chemistry.chemical_compound Breast cancer Vitamin D - Breast cancer - Carcinogenesis - Prevention - Treatment Internal medicine Vitamin D and neurology Medicine Neoplastic transformation lcsh:RC31-1245 Aromatase inhibitor business.industry lcsh:Other systems of medicine lcsh:RZ201-999 medicine.disease Endocrinology Oncology chemistry Cancer research business Carcinogenesis |
| Zdroj: | Oncology Reviews, Vol 3, Iss 1 (2011) |
| ISSN: | 1970-5565 1970-5557 |
| DOI: | 10.1007/s12156-009-0003-x |
| Popis: | The biological role of vitamin D outside of calcium homeostasis is still under evaluation. The ability of vitamin D to inhibit cell proliferation and induce differentiation makes it a potential modifier of neoplastic transformation. Vitamin D affects the cell cycle, apoptosis, hormone receptors, angiogenesis, and hypoxia, all of which are related to the breast cancer growth, progression and metastasis. A large percentage of the industrial-world population is deficient in vitamin D. Epidemiological evidence suggests that vitamin D deficiency increases the risk of breast cancer. Vitamin D may have synergistic, additive, or antagonistic effects when combined with other therapeutic agents against breast cancer. Vitamin D appears to depress aromatase inhibitor by acting through cytochrome P 450. This evidence along with pre-clinical and clinical studies, justify the inclusion of vitamin D in future clinical trials related to breast cancer in order to determine its efficacy as a part of the breast cancer therapeutic armament. |
| Databáze: | OpenAIRE |
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