Endothelial Damage-dominant Nephritis Related to IgA Vasculitis after 11 Years' Use of Infliximab for Rheumatoid Arthritis

Autor:	Makoto, Fukuda, Naoki, Sawa, Daisuke, Ikuma, Yuki, Oba, Hiroki, Mizuno, Masayuki, Yamanouchi, Akinari, Sekine, Eiko, Hasegawa, Tatsuya, Suwabe, Junichi, Hoshino, Kei, Kono, Keiichi, Kinowaki, Kenichi, Ohashi, Hiromichi, Tamaki, Motoaki, Miyazono, Yoshifumi, Ubara
Rok vydání:	2023
Předmět:	Adult Arthritis Rheumatoid Proteinuria Methotrexate Nephritis IgA Vasculitis Internal Medicine Humans Female General Medicine Infliximab Purpura
Zdroj:	Internal Medicine. 62:81-85
ISSN:	1349-7235 0918-2918
Popis:	A 43-year-old Japanese woman with rheumatoid arthritis treated by infliximab and methotrexate for 11 years was admitted for proteinuria and purpura. A kidney biopsy revealed endothelial damage-dominant nephritis with IgA deposition. Infliximab and methotrexate were discontinued, and tocilizumab was started; however, proteinuria persisted. Therefore, tocilizumab was discontinued, and oral prednisolone and methylprednisolone pulse therapy were administered. After 6 months, urinary protein was less than 0.1 g/day, and purpura subsided. To our knowledge, this is the first case of endothelial damage-dominant nephritis related to IgA vasculitis involving the skin and kidney after long-term use of infliximab and methotrexate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf0447cd8a53e03c17a2cb6599c8d73 https://doi.org/10.2169/internalmedicine.9059-21 Zobrazit plný text záznamu