Antidepressant Effect of Aminophylline After Ethanol Exposure
| Autor: | Danielle Silveira Macêdo, Anália Barbosa Almeida, Manoel Cláudio Azevedo Patrocínio, Paula Matias Soares, Francisca Cléa Florenço de Sousa, Silvânia Maria Mendes Vasconcelos, Rodrigo De Freitas Guimarães Lobato, Dayane Pessoa de Araújo, Sarah de Souza Escudeiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Córtex pré-frontal
Monoamines Behavior Ethanol Adenosine Etanol Chemistry Metabolite Adenosina Pharmaceutical Science Adenosinergic Pharmacology Aminophylline Prefrontal cortex Norepinephrine (medication) chemistry.chemical_compound Monoamine neurotransmitter Dopamine medicine Antidepressant Research Article medicine.drug |
| Zdroj: | Scientia Pharmaceutica Volume 81 Issue 1 Pages 211-222 CIÊNCIAVITAE Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| ISSN: | 2218-0532 |
| DOI: | 10.3797/scipharm.1208-17 |
| Popis: | This work investigated the association of acute ethanol and aminophylline administration on behavioral models of depression and prefrontal monoamine levels (i.e. norepinephrine and dopamine) in mice. The animals received a single dose of ethanol (2 g/kg) or aminophylline (5 or 10 mg/kg) alone or in association. Thirty minutes after the last drug administration, the animals were assessed in behavioral models by the forced swimming and tail suspension tests. After these tests, the animals were sacrificed and the prefrontal cortices dissected to measure monoamine content. Results showed that ethanol presented depression-like activity in the forced swimming and tail suspension tests. These effects were reversed by the association with aminophylline in all tests. Norepinephrine and dopamine levels decreased, while an increase in the dopamine metabolite, (4-hydroxy-3-methoxyphenyl)acetic acid (DOPAC), after ethanol administration was observed. On the contrary, the association of ethanol and aminophylline increased the norepinephrine and dopamine content, while it decreased DOPAC when compared to the ethanol group, confirming the alterations observed in the behavioral tests. These data reinforce the involvement of the adenosinergic system on ethanol effects, highlighting the importance of the norepinephrine and dopamine pathways in the prefrontal cortex to the effects of ethanol. |
| Databáze: | OpenAIRE |
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