Complement Receptor Type 1 Gene Regulation: Retinoic Acid and Cytosine Arabinoside Increase CR1 Expression
| Autor: | T A Funkhouser, D. P. Vik |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Neutrophils
Immunology Dose-Response Relationship Immunologic Retinoic acid HL-60 Cells Tretinoin Retinoic acid receptor beta Biology Monocytes Interferon-gamma chemistry.chemical_compound Complement Receptor Type 1 Humans RNA Messenger Regulation of gene expression Interleukin-6 Tumor Necrosis Factor-alpha Cytarabine Granulocyte-Macrophage Colony-Stimulating Factor U937 Cells General Medicine Retinoic acid receptor gamma Molecular biology Complement system Kinetics Retinoic acid receptor Haematopoiesis Gene Expression Regulation chemistry Receptors Complement 3b K562 Cells Interleukin-1 |
| Zdroj: | Scandinavian Journal of Immunology. 49:21-28 |
| ISSN: | 1365-3083 0300-9475 |
| DOI: | 10.1046/j.1365-3083.1999.00455.x |
| Popis: | Complement receptor type 1 (CR1) is expressed principally on erythrocytes, monocytes, neutrophils and B cells, where it acts as a negative regulator of the complement cascade and as a clearance mechanism for immune complexes. As CR1 expression occurs in a number of lineages, its regulation may parallel other steps in haematopoiesis. Several leucocyte-cell lines (including K-562, THP-1, U-937 and HL-60) and B-cell lines, as well as peripheral blood cells (PBCs), were tested for the ability of various compounds to up-regulate their CR1 expression. While most of the compounds tested had minimal effects on CR1 message level, retinoic acid induced increases in mRNA levels in nearly all cell lines studied. Furthermore, in K-562 cells, the cytosine analogue Ara-C, an inducer of erythroid differentiation, caused the highest increases in CR1 mRNA levels as compared to untreated cells. Ara-C also induced significant increases in CR1 message in PBCs. These data suggest that induction of specific CR1 expression could be an integral part of blood cell differentiation and that the identified cell induction systems may be useful as models to study the regulation of CR1 gene expression. |
| Databáze: | OpenAIRE |
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