Reinterpreting recent thymic emigrant function: defective or adaptive?
| Autor: | Eric Y Helm, Cody A. Cunningham, Pamela J. Fink |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cellular differentiation T cell Immunology Adaptation Biological Recent Thymic Emigrant Thymus Gland Biology Lymphocyte Activation Article Immune tolerance 03 medical and health sciences 0302 clinical medicine Immune system Cell Movement T-Lymphocyte Subsets Immune Tolerance medicine Animals Humans Immunology and Allergy Compartment (development) Regulation of gene expression Thymocytes Gene Expression Regulation Developmental Cell Differentiation Cell biology 030104 developmental biology medicine.anatomical_structure Cellular Microenvironment Self Tolerance Biomarkers Signal Transduction 030215 immunology |
| Zdroj: | Current Opinion in Immunology. 51:1-6 |
| ISSN: | 0952-7915 |
| DOI: | 10.1016/j.coi.2017.12.006 |
| Popis: | Recent thymic emigrants (RTEs) are those peripheral T cells that have most recently completed thymic development and egress. Over the past decade, significant advances have been made in understanding the cell-extrinsic and cell-intrinsic requirements for RTE maturation to mature naïve (MN) T cells and in detailing the functional differences that characterize these two T cell populations. Much of this work has suggested that RTEs are hypo-functional versions of more mature T cells. However, recent evidence has indicated that rather than being defective T cells, RTEs are exquisitely adapted to their cellular niche. In this review, we argue that RTEs are not flawed mature T cells but are adapted to fill an underpopulated T cell compartment, while maintaining self tolerance and possessing the capacity to mount robust immune responses. |
| Databáze: | OpenAIRE |
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