Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens
| Autor: | Svein Hansen, Odd Geiran, Svein Simonsen, Petter Jensen, Per Pfeffer, P. Fauchald, Bjørn Møller, Torbjørn Leivestad |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Adolescent medicine.medical_treatment Population Azathioprine Dermatology Gastroenterology Organ transplantation Cohort Studies Age Distribution Risk Factors Internal medicine Humans Medicine Child education Melanoma Sarcoma Kaposi Kidney transplantation Aged Aged 80 and over Heart transplantation education.field_of_study business.industry Infant Immunosuppression Middle Aged medicine.disease Kidney Transplantation Surgery stomatognathic diseases Child Preschool Multivariate Analysis Carcinoma Squamous Cell Prednisolone Heart Transplantation Female Skin cancer business Immunosuppressive Agents medicine.drug |
| Zdroj: | Journal of the American Academy of Dermatology. 40:177-186 |
| ISSN: | 0190-9622 |
| Popis: | Background: Nonmelanoma skin cancer occurs frequently in organ transplant recipients, but the relative importance of different immunosuppressive therapy regimens is unclear. Objective: We studied the risk of skin cancer in the complete, single-center Norwegian cohort of kidney and heart transplant recipients (n = 2561). Methods: We determined cancer risk estimation by means of standardized incidence ratios and multivariate Cox regression. Results: Transplant recipients had an increased risk of cutaneous squamous cell carcinoma (SCC) (65-fold), malignant melanoma (3-fold), and Kaposi's sarcoma (84-fold), and of lip SCC (20-fold), compared with the general population. After adjustment for age, kidney transplant recipients receiving cyclosporine, azathioprine, and prednisolone had a significantly (2.8 times) higher risk of cutaneous SCC relative to those receiving azathioprine and prednisolone. After adjustment for age and type of immunosuppressive regimen, heart transplant recipients had a significantly (2.9 times) higher risk than kidney transplant recipients. Conclusion: The risk of cutaneous SCC, malignant melanoma, Kaposi's sarcoma, and lip SCC is increased in kidney and heart transplant recipients. The risk of posttransplant cutaneous SCC is related to the degree of immunosuppression caused by long-term immunosuppressive therapy. (J Am Acad Dermatol 1999;40:177-86.) |
| Databáze: | OpenAIRE |
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