n-Butyl Cyanoacrylate Synthesis. A New Quality Step Using Microwaves
| Autor: | Rubén Álvarez Brito, Ricardo Martínez Sánchez, Wolf-Dieter Mueller, Paola Rodríguez Domínguez, Elayma Sánchez Acevedo, Yaquelin Ramos Carriles |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Materials science
Pharmaceutical Science Article Analytical Chemistry law.invention lcsh:QD241-441 lcsh:Organic chemistry law Drug Discovery n-butyl cyanoacrylate Organic chemistry Humans Physical and Theoretical Chemistry Microwaves Alkyl chemistry.chemical_classification poly (n-butyl cyanoacrylate) microwaves irradiation Wound Healing N-butyl-cyanoacrylate Organic Chemistry Enbucrilate Cyanoacrylates chemistry Chemical engineering Chemistry (miscellaneous) Cyanoacrylate Yield (chemistry) Molecular Medicine Knoevenagel condensation Tissue Adhesives Adhesive Microwave |
| Zdroj: | Molecules, Vol 19, Iss 5, Pp 6220-6227 (2014) Molecules Molecules; Volume 19; Issue 5; Pages: 6220-6227 |
| ISSN: | 1420-3049 |
| Popis: | Alkyl cyanoacrylates are interesting products for use in industry because of their properties enabling them to stick together a wide range of substrates. n-Butyl cyanoacrylate is one of the most successfully used tissue adhesives in the field of medicine because it exhibits bacteriostatic and haemostatic characteristics, in addition to its adhesive properties. At present, its synthesis is performed with good yields via Knoevenagel condensation using conventional sources of heating, but this requires a long processing time. The aim of this work was to look for a new way of synthesising n-butyl cyanoacrylate using microwave irradiation as the source of heating. This non-conventional source of heating most likely reduces the process time of the synthesis. In comparison with a conventional heating source, such as an oil bath, the results showed the advantages of this method whereby the n-butyl cyanoacrylate gave the same yield and quality with a reduction in the reaction time by a factor of 3-5-fold. |
| Databáze: | OpenAIRE |
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