Estimation of lean body mass in children
| Autor: | D.M. Glass, Hayley Snelling, A.M. Peters, N.J. Bird |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Aging Pediatrics medicine.medical_specialty Adolescent medicine.medical_treatment Urology Renal function Body weight Kidney transplant Drug Administration Schedule Body Mass Index Young Adult Reference Values medicine Humans Child Aged Anesthetics Sex Characteristics Anthropometry business.industry Body Weight Infant Extracellular Fluid Middle Aged Body Height Anesthesiology and Pain Medicine Child Preschool Reference values External cephalic version Lean body mass Linear correlation business Body mass index Glomerular Filtration Rate |
| Zdroj: | British Journal of Anaesthesia. 106:719-723 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/aer057 |
| Popis: | BACKGROUND In adults, dosages of some anaesthetic agents are based on lean body mass (LBM) rather than body weight. Our aim was to derive an equation for estimating LBM in children. METHODS Patients comprised three groups: prospective kidney transplant donors from two separate centres (centres 1 and 3) and children referred to a further centre (centre 2) for the routine clinical measurement of glomerular filtration rate (GFR). GFR and extracellular fluid volume (ECV) were measured using Cr-51-EDTA. LBM was directly estimated (eLBM) in adults using an equation based on height and weight. ECV in children was estimated (eECV) from another equation based on height and weight, converted to eLBM using the relationship between eLBM and ECV determined in the adults from centre 1 and then compared with adult data from centre 3. RESULTS In children, the ratio of eECV to ECV was 1.04 (SD 0.18). In centre 1, eLBM (kg) was 3.81 (SD 0.55) times greater than ECV (litres) in men (n=50) and 3.77 (0.77) times greater in women (n=51). eLBM in children was therefore derived by multiplying eECV by 3.8. In children, eLBM showed a close linear correlation with measured ECV (eLBM=3.50ECV+2.0; R(2)=0.857), similar to adults (eLBM=2.82ECV+14.5; R(2)=0.582). In all groups, eLBM/weight correlated inversely with weight. CONCLUSIONS In terms of the relationships between eLBM, ECV, and weight, children are similar to adults. Therefore, drug dosage in children should also be based on eLBM rather than weight |
| Databáze: | OpenAIRE |
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