Acute and subacute toxicity study of Aucklandia lappa Decne seed oil
| Autor: | Chunlan Su, Qin Liang, Xue Zhang, Xian Yang, Tingting Li, Peng Du, Ting Zeng, Jia Ran |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Hematology biology business.industry Significant difference Subacute toxicity Pharmaceutical Science Aucklandia lappa Physiology biology.organism_classification Acute toxicity Aucklandia lappa seed oil Acute toxicity Rodents Subacute toxicity Histological features Hematological properties Food resources Internal medicine Medicine Pharmacology (medical) Histopathology business Organ weight |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol. 20 No. 10 (2021); 2117-2125 |
| ISSN: | 1596-9827 1596-5996 |
| Popis: | Purpose: To investigate the acute and subacute toxicity of Aucklandia lappa Decne. seed oil (ALDO) in mice and rats.Methods: A single dose of 10 g ALDO/kg was administered to Kunming mice in an acute oral toxicity experiment. Their weight and feed consumption were recorded for 14 days to observe whether they had symptoms of poisoning and mortality. Sprague-Dawley (SD) rats were administered 0.89, 1.77 and 3.54 g/kg for 28 days, and symptoms of poisoning and mortality were monitored daily. Body weight, feedconsumption, hematology, serum biochemical parameters, relative organ weight, and histopathology of the experimental and control groups were compared.Results: The acute oral toxicity study revealed that there was no significant difference in the macroscopic results, including mortality, feed consumption and weight growth between the group dosed with 10 g ALDO/kg (p > 0.05) and the control group. In the subacute toxicity test, SD rats had a higher weight growth rate and feed utilization after doses of 0.89 g ALDO/kg (p < 0.01). However, compared with the control group (p > 0.05), there was also no significant difference in biochemical and hematological parameters, relative organ weight, or in macroscopic and histological features of both animal types. The electrolyte concentrations of Na and Cl increased at the doses of 1.77 and 3.54 g/kg (p < 0.01).Conclusion: These results suggest that ALDO is relatively safe when administered orally to rats and provide a theoretical basis for the development of new food resources. |
| Databáze: | OpenAIRE |
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