Three new diterpenes and the biological activity of different extracts of Jasonia montana
| Autor: | Adnan J. Al-Rehaily, Jaber S. Mossa, Tawfeq A. Al-Howiriny, Polsc, Bahar Ahmed, Porter |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Flavonoids
Centaureidin Chloroform biology Plant Extracts Stereochemistry Organic Chemistry Jasonia Biological activity Microbial Sensitivity Tests Plant Science Asteraceae biology.organism_classification Antimicrobial Biochemistry Analytical Chemistry chemistry.chemical_compound chemistry Hypoglycemic Agents Petroleum ether Diterpenes Spectral data |
| Zdroj: | Natural Product Research. 19:253-265 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Three new diterpenes, namely jasonin-a (1), jasonin-b (2), and jasonin-c (3) were isolated from the aerial parts of Jasonia montana (Asteraceae). Their structures were elucidated on the basis of spectral data as [(1E)-2-((2S)-1,2,5-trimethylbicyclo[3.2.l]octan-8-yl)vinyl] benzene-3-carboxylic acid (1), [3-((2S, 5S)-1,2, 5-trimethylcycloheptanyl)propyl]benzene-3-carboxylic acid (2), and [(1E)-3-((7R)-1,7-dimethy-4-methylenecycloheptanyl)prop-1-enyl] benzene-3-carboxylic acid (3). In addition, the previously reported 5,7,3'-trihydroxy-3,6,4'-trimethoxy flavone designated as centaureidin (4), was also isolated and characterized from this source. The different extracts of the plant were also screened for hypoglycemic, antidiabetic, and antimicrobial activities, wherein the petroleum ether and ethanolic extracts exhibited hypoglycemic and antidiabetic activity, and the petroleum ether and chloroform extracts showed antimicrobial activity. |
| Databáze: | OpenAIRE |
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