IgE deposition in brain microvessels and on parasitized erythrocytes from cerebral malaria patients
| Autor: | K. Win, Koki Taniguchi, Sornchai Looareesuwan, Toshio Nakabayashi, Peter Perlmann, PerlmannH, Yasuhiro Kusuhara, Yoshimasa Maeno, Masamichi Aikawa |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Erythrocytes Adolescent Plasmodium falciparum Malaria Cerebral Antigens Protozoan Antigen-Antibody Complex Immunoglobulin E Pathogenesis Immune system Antigen Virology parasitic diseases medicine Animals Humans Aged biology Microcirculation Brain Middle Aged Immunohistochemistry Red blood cell Infectious Diseases medicine.anatomical_structure Cerebral Malaria Immunology biology.protein Female Parasitology Endothelium Vascular Antibody Blood vessel |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 63:128-132 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Postmortem brain tissues of 21 cerebral malaria cases were obtained in Myanmar and Vietnam. The tissues were examined by light microscopy and by an immunohistochemical method. Brain microvessels (capillaries and venules) were examined for the presence of immunoglobulins IgE and IgG, Plasmodium falciparum antigen, and parasitized erythrocytes (PRBC). Deposition of IgE, IgG, and P. falciparum antigen was observed in the microvessels from all specimens examined. Sequestered PRBC in the microvessels were positive for IgG in all 21 cases and for IgE in six cases. In the latter cases, the percentage of microvessels with sequestered PRBC was > 50%, with the frequency of IgE-positive cells ranging from 42% to 52%. In contrast, in five cases that were only weakly positive for IgE, the percentage of microvessels with sequestered PRBC was remarkably low (< 1%). These data indicate that the degree of deposition of IgE in microvessels and on PRBC from cerebral malaria patients correlated with that of PRBC sequestration. As IgE-containing immune complexes are known to induce local overproduction of tumor necrosis factor-alpha (TNF-alpha), a major pathogenic factor in cerebral malaria, IgE may contribute to the pathogenesis of this severe disease. |
| Databáze: | OpenAIRE |
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