EFFECT OF FETAL DIAGNOSTIC TESTING ON BIRTH-RATE OF THALASSAEMIA MAJOR IN BRITAIN
| Autor: | B Modell, D.V.I Faireweather, L. Varnavides, J.M. White, C. H. Rodeck, M Petrou, R.H.T Ward |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Risk Pediatrics medicine.medical_specialty Genetic counseling Thalassemia Ethnic group India Genetic Counseling Prenatal diagnosis Abortion Birth rate Pregnancy Prenatal Diagnosis medicine Humans Pakistan Fetus business.industry Obstetrics Genetic Carrier Screening General Medicine Africa Eastern medicine.disease United Kingdom Cyprus Female business |
| Zdroj: | The Lancet. 324:1383-1386 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(84)92070-1 |
| Popis: | A programme of prospective heterozygote detection and counselling, fetal diagnostic testing, and abortion of fetuses affected by thalassaemia major introduced in Britain in 1977 has proved highly acceptable to at-risk couples of Cypriot and East African Asian origin, but less so to couples of Pakistani origin. However, many at-risk couples are still not detected prospectively, the proportion of thalassaemia-major births prevented was only 32% by the end of 1981, and there is little evidence of a further fall since then. The thalassaemia-major birth-rate had fallen by 60% in Cypriots and by 20% in East African Asians, but it had not fallen at all in Pakistanis. Improved approaches to fetal diagnosis of thalassaemia major are becoming available, so a concerted effort is needed to inform all the at-risk ethnic groups of the existence of the problem and the possibility of detection of affected fetuses. |
| Databáze: | OpenAIRE |
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