Thrombophilia in hepatocellular carcinoma
| Autor: | Thoraya A.M. Hosny, Fayrouz Othman Selim, Taghrid Mohamed Abdalla |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Hyperhomocysteinemia
medicine.medical_specialty Hepatocellular carcinoma lcsh:Surgery Chronic liver disease Thrombophilia Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Factor V Leiden lcsh:RC799-869 neoplasms General Environmental Science Prothrombin time medicine.diagnostic_test business.industry lcsh:RD1-811 medicine.disease digestive system diseases 030220 oncology & carcinogenesis Liver cirrhosis General Earth and Planetary Sciences lcsh:Diseases of the digestive system. Gastroenterology 030211 gastroenterology & hepatology Activated protein C resistance business Protein C Venous thromboembolism medicine.drug |
| Zdroj: | Egyptian Liver Journal, Vol 9, Iss 1, Pp 1-7 (2019) |
| ISSN: | 2090-6226 |
| Popis: | Background Chronic liver disease and hepatocellular carcinoma (HCC) can cause a disturbance in the coagulation system. In this study, we aimed to assess the risk factors for venous thromboembolism either acquired or hereditary in patients with HCC. Results Serum levels of proteins C and S, AT activity, and lipoprotein (a) were significantly lower in both HCC and cirrhotic patients while homocysteine levels were significantly higher in HCC patients. The prevalence of activated protein C resistance (APCR) and factor V Leiden (FVL) mutation was higher in HCC patients but with no significant differences between the studied groups. With multivariate analysis, prothrombin time, Fbg, protein C and S deficiency, increased lipoprotein (a), hyperhomocysteinemia, APCR, and FVL mutation were independent risk factors for thromboembolic complications in HCC patients. Conclusions Thrombophilic abnormalities are prevalent in HCC patients, and they have a substantial increased risk of venous thromboembolism. |
| Databáze: | OpenAIRE |
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