Ezetimibe Effectively Reduces Plasma Plant Sterols in Patients With Sitosterolemia
| Autor: | B. Musser, John P. Kane, K. von Bergmann, D. Lütjohann, P. Stein, Shailendra B. Patel, T. Musliner, P. Kwiterovich, G. Salen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Arteriosclerosis Lipoproteins Campesterol Genes Recessive Placebo Lipid Metabolism Inborn Errors Article Intestinal absorption Cholesterol Dietary chemistry.chemical_compound Double-Blind Method Ezetimibe Physiology (medical) Internal medicine medicine Humans ATP Binding Cassette Transporter Subfamily G Member 5 Child Aged Apolipoproteins B Cholesterol business.industry Anticholesteremic Agents ATP Binding Cassette Transporter Subfamily G Member 8 Phytosterols Middle Aged medicine.disease Sitosterols Sterol Treatment Outcome Endocrinology Intestinal Absorption chemistry Azetidines ATP-Binding Cassette Transporters Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Sitosterolemia medicine.drug |
| Zdroj: | Circulation. 109:966-971 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000116766.31036.03 |
| Popis: | Background— Sitosterolemia is a recessively inherited disorder that results from mutations in either ABCG5 or G8 proteins, with hyperabsorption of dietary sterols and decreased hepatic excretion of plant sterols and cholesterol. As a consequence of markedly elevated plasma and tissue sitosterol and campesterol levels, premature atherosclerosis develops. Methods and Results— In this multicenter, double-blind, randomized, placebo-controlled study, we examined whether treatment with ezetimibe, an inhibitor of cholesterol absorption, reduces plant sterol levels in patients with sitosterolemia. After a 3-week placebo run-in, 37 patients were randomized to receive placebo (n=7) or ezetimibe 10 mg/d (n=30) for 8 weeks. Sitosterol concentrations decreased by 21% ( P P P Conclusions— Ezetimibe produced significant and progressive reductions in plasma plant sterol concentrations in patients with sitosterolemia, consistent with the hypothesis that ezetimibe inhibits the intestinal absorption of plant sterols as well as cholesterol, leading to reductions in plasma concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|