Interferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans

Autor: Paul L. Auer, Russell P. Tracy, Colton Leavitt, Neil A. Zakai, Nels C. Olson, Mary Cushman, Timothy A. Thornton, James G. Wilson, Ethan M. Lange, Laura M. Raffield, Alexander P. Reiner, Emily B. Levitan, Leslie A. Lange
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Epidemiology
Disease
030204 cardiovascular system & hematology
Cardiovascular Medicine
Left ventricular hypertrophy
Vascular Medicine
Biochemistry
Carotid Intima-Media Thickness
White Blood Cells
0302 clinical medicine
Animal Cells
Risk Factors
Medicine and Health Sciences
Longitudinal Studies
Stroke
Subclinical infection
Multidisciplinary
T Cells
Hazard ratio
Middle Aged
Lipids
Cholesterol
C-Reactive Protein
Neurology
Cardiovascular Diseases
Cohort
Medicine
Female
Cellular Types
Research Article
medicine.medical_specialty
Science
Cerebrovascular Diseases
Immune Cells
Immunology
Cardiology
Microbiology
03 medical and health sciences
Interferon-gamma
Internal medicine
Virology
medicine
Humans
Proportional Hazards Models
Heart Failure
Blood Cells
Proportional hazards model
business.industry
Biology and Life Sciences
Cell Biology
medicine.disease
Black or African American
Chemokine CXCL10
030104 developmental biology
Heart failure
Medical Risk Factors
business
Biomarkers
Viral Transmission and Infection
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231013 (2020)
ISSN: 1932-6203
Popis: Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely unexamined. We hypothesized the cytokine interferon gamma inducible protein 10 (IP-10) would be associated with clinical and subclinical cardiovascular disease and all-cause mortality in African Americans. We assessed these associations in the Jackson Heart Study (JHS) cohort and the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. There was a modest association of IP-10 with higher odds of left ventricular hypertrophy (OR = 1.20 (95% confidence interval (CI) 1.03, 1.41) per standard deviation (SD) higher natural log-transformed IP-10 in JHS). We did not observe associations with ankle brachial index, intima-media thickness, or arterial calcification. Each SD higher increment of ln-transformed IP-10 concentration was associated with incident heart failure (hazard ratio (HR) 1.26; 95% CI 1.11, 1.42, p = 4x10-4) in JHS, and with overall mortality in both JHS (HR 1.12 per SD, 95% CI 1.03, 1.21, p = 7.5x10-3) and REGARDS (HR 1.31 per SD, 95% CI 1.10, 1.55, p = 2.0 x 10-3), adjusting for cardiovascular risk factors and C-reactive protein. However, we found no association between IP-10 and stroke or coronary heart disease. These results suggest a role of IP-10 in heart failure and mortality risk independent of C-reactive protein. Further research is needed to investigate how the body's response to chronic viral infection may mediate heart failure and overall mortality risk in African Americans.
Databáze: OpenAIRE
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