Antioxidant deficit and enhanced susceptibility to oxidative damage in individuals with different forms of alpha-thalassaemia
| Autor: | Hsiu-chuan Tseng, Chien-Hong Lee, Daniel Tsun-Yee Chiu, Hung-Yao Ho, Mei-Ling Cheng, Lee-Yung Shih |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant Erythrocytes medicine.medical_treatment Ascorbic Acid medicine.disease_cause Antioxidants Superoxide dismutase Lipid peroxidation chemistry.chemical_compound alpha-Thalassemia Internal medicine Erythrocyte Deformability medicine TBARS Humans Vitamin E Vitamin A chemistry.chemical_classification Reactive oxygen species Analysis of Variance Hemoglobin H biology Superoxide Dismutase Hematology Catalase Glutathione Oxidative Stress Endocrinology Biochemistry chemistry Case-Control Studies biology.protein Female Disease Susceptibility Lipid Peroxidation Oxidative stress |
| Zdroj: | British journal of haematology. 128(1) |
| ISSN: | 0007-1048 |
| Popis: | alpha-Thalassaemia is a common red cell disorder in Taiwan, affecting 6-8% of Taiwanese. Previous studies have shown that reactive oxygen species are generated in increased amounts in thalassaemic red cells. This implies the possible alteration of redox status in thalassaemic patients, which may adversely affect their health. In the present study, the redox status of patients with alpha-thalassaemia trait and haemoglobin H (Hb H) disease was investigated. Lipid peroxidation, as measured by the level of plasma thiobarbituric acid reactive substances (TBARS), was increased in alpha-thalassaemic patients, with the highest level of TBARS in Hb H disease patient. The plasma levels of vitamin A, C, and E were significantly lower in alpha-thalassaemic patients than in controls. The overall antioxidant capacity in plasma was inversely correlated with the severity of alpha-globin gene defect: the more severe the form of alpha-thalassaemia, the lower the overall antioxidant capacity in plasma. Erythrocytes isolated from alpha-thalassaemia patients had lower levels of vitamin E, glutathione, catalase and superoxide dismutase. In addition, these alpha-thalassaemic red cells were more susceptible to hydrogen peroxide-induced lipid peroxidation and decrease in deformability. All these data suggest that the alpha-thalassaemic patients suffer from increased oxidative stress and antioxidant deficit, which may complicate the pathophysiology of alpha-thalassaemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text