Comparative Analysis of Gene Expression Profiles Involved in Calcium Signaling Pathways Using the NLVH Animal Model of Schizophrenia
| Autor: | Carlos Alfonso Tovilla-Zárate, Thelma Beatriz González-Castro, Sandra Morales-Mulia, Humberto Nicolini, Lilia López-Narváez, Ileana Gallegos-Silva, Alma Delia Genis-Mendoza, Mavil López-Casamichana, Yazmín Hernández-Díaz |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hippocampus Nucleus accumbens Hippocampal formation Biology Sarcoplasmic Reticulum Calcium-Transporting ATPases Lesion 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Internal medicine Gene expression medicine Animals Calcium Signaling Mechanisms of schizophrenia Rats Wistar Prefrontal cortex Calcineurin Gene Expression Profiling General Medicine Rats Gene expression profiling Focal Adhesion Kinase 2 030104 developmental biology Endocrinology Schizophrenia Calcium Channels medicine.symptom 030217 neurology & neurosurgery Adenylyl Cyclases |
| Zdroj: | Journal of Molecular Neuroscience. 64:111-116 |
| ISSN: | 1559-1166 0895-8696 |
| DOI: | 10.1007/s12031-017-1013-y |
| Popis: | In this study, we evaluated the expression profile changes of genes that intervene in the calcium signaling pathway, in young and adult Wistar rats, using the animal model of neonatal lesion in ventral hippocampus (NLVH) (a recognized animal model for schizophrenia) and compared to the group of control animals (Sham). Through microarray technology, gene expression profiles were obtained from the three brain areas (nucleus accumbens, prefrontal cortex, and hippocampus) of young male Wistar rats (45 days) and adults (90 days) whether or not subjected to NLVH. The calcium signaling pathway reported a greater number of differentially expressed genes with z-score two values, > 2 (over-expression) and |
| Databáze: | OpenAIRE |
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