Short-term but not long-term high-fat diet induces an increase in gene expression of gonadotropic hormones and GPR120 in the male mouse pituitary gland

Autor: Ryutaro Moriyama, Chikaya Deura
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Time Factors
Follicle-stimulating hormone (FSH)
GPR120
Gene Expression
High-fat diet (HFD)
Gonadotrophs
Biology
Gonadotropic cell
Diet
High-Fat
FSHB
Receptors
G-Protein-Coupled
03 medical and health sciences
Mice
0302 clinical medicine
Internal medicine
Gene expression
medicine
Animals
Receptor
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
030219 obstetrics & reproductive medicine
Luteinizing hormone (LH)
digestive
oral
and skin physiology
Fatty acid
nutritional and metabolic diseases
food and beverages
Luteinizing Hormone
beta Subunit
Endocrinology
chemistry
Pituitary
Hormone receptor
Pituitary Gland
Follicle Stimulating Hormone
beta Subunit
Animal Science and Zoology
Original Article
Luteinizing hormone
hormones
hormone substitutes
and hormone antagonists
Receptors
LHRH
Hormone
Zdroj: The Journal of Reproduction and Development
ISSN: 1348-4400
0916-8818
Popis: High-fat diet (HFD) is associated with the regulation of reproductive functions. This study aimed to investigate the effects of short-term HFD on the mRNA expression levels of follicle-stimulating hormone β subunit (FSHβ), luteinizing hormone β subunit (LHβ), gonadotropin-releasing hormone receptor, and long-chain fatty acid receptor, GPR120, in the matured male mouse pituitary gland. Adult male mice were fed either control chow or HFD for 1, 2, 5, 10, 30 and 150 days. Fshb and Gpr120 mRNA expression levels in the pituitary glands were significantly increased during 2 to 30 days of HFD feeding. Gnrh-r mRNA in the 30 days HFD fed group and body weight in the 30 and 150 days HFD fed groups were higher than control. However, there were no significant differences in plasma non-esterified fatty acids or glucose levels during the 150 days of HFD feeding. These results suggest that male mice feeding a short-term HFD induces FSHβ synthesis and GPR120 expression in their pituitary gonadotropes.
Databáze: OpenAIRE
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