Absorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects
| Autor: | Toshikazu Komoda, Naoki Shimizu, Takahiro Eitsuka, Kiyotaka Nakagawa, Tojiro Tsushida, Natsumi Hayasaka, Satoshi Mohri, Teruo Miyazawa |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.drug_class Flavonoid Administration Oral Absorption (skin) Pharmacology Anti-inflammatory Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Mice Young Adult 0302 clinical medicine Glucosides Tandem Mass Spectrometry medicine Animals Humans Animal species Luteolin chemistry.chemical_classification Molecular Structure General Chemistry Metabolism Middle Aged In vitro Rats Plant Leaves 030104 developmental biology Aglycone RAW 264.7 Cells chemistry 030220 oncology & carcinogenesis General Agricultural and Biological Sciences Capsicum Chromatography Liquid |
| Zdroj: | Journal of agricultural and food chemistry. 66(43) |
| ISSN: | 1520-5118 |
| Popis: | Luteolin is a flavonoid present in plants in the form of aglycone or glucosides. In this study, luteolin glucosides (i.e., luteolin-7- O-β-d-glucoside, luteolin-7- O-[2-(β-d-apiosyl)-β-d-glucoside], and luteolin-7- O-[2-(β-d-apiosyl)-6-malonyl-β-d-glucoside]) prepared from green pepper leaves as well as luteolin aglycone were orally administered to rats. Regardless of the administered luteolin form, luteolin glucuronides were mainly detected from plasma and organs. Subsequently, luteolin aglycone, the most absorbed form of luteolin in rats, was orally administered to humans. As a result, luteolin-3'- O-sulfate was mainly identified from plasma, suggesting that not only luteolin form but also animal species affect the absorption and metabolism of luteolin. When LPS-treated RAW264.7 cells were treated with luteolin glucuronides and luteolin sulfate (the characteristic metabolites identified from rats and humans, respectively), the different luteolin conjugates were metabolized in different ways, suggesting that such difference in metabolism results in their difference in anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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