18F-fluorodeoxyglucose PET/computed tomography in locoregional staging and assessment of biological and clinical aggressiveness of breast cancer subtypes
| Autor: | Elif E Ozkan, S Süreyya Sengul, Mehmet Ozgur Erdogan, H Erol Eroglu, Osman Gürdal |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Sentinel lymph node Breast Neoplasms Computed tomography 030218 nuclear medicine & medical imaging Fluorodeoxyglucose PET 03 medical and health sciences 0302 clinical medicine Breast cancer Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Biopsy medicine Humans Radiology Nuclear Medicine and imaging Lymph node Aged Neoplasm Staging Retrospective Studies Positron Emission Tomography-Computed Tomography medicine.diagnostic_test business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease medicine.anatomical_structure ROC Curve 030220 oncology & carcinogenesis Female Radiology business |
| Zdroj: | Nuclear Medicine Communications. 40:1043-1050 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0000000000001073 |
| Popis: | We aimed to evaluate the availability of fluorine-18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) in initial axillary lymph node (ALN) staging in breast cancer. The secondary objective is to evaluate the role of FDG PET/CT as a pretest in sentinel lymph node biopsy vs. axillary lymph node dissection when predicting disease aggressiveness.The study evaluated retrospectively 194 breast cancer patients who underwent preoperative 18F-FDG. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of FDG PET/CT for ALN metastases were confirmed with histopathology as the gold standard.The value of the area under curve (AUC), sensitivity and specificity for ALN metastases were determined as 0.847, 78.8% and 92.6%, respectively. The cut-off value of the maximum standardized uptake value (SUVmax) for metastatic ALN detection was calculated as 1.79. PPV, NPV and the accuracy of 18F-FDG PET/CT were 0.933 (93.3%), 0.75 (75%) and 0.837 (83.7%), respectively. The SUVmax value of the primary lesion was significantly correlated with grade, estrogen receptor (ER) status, progesterone receptor (PR) status, SUVmax value of metastatic ALN, Her-2 status and Ki-67 level. Molecular subtypes revealed no statistically significant difference in terms of mean SUVmax value.High values of AUC, sensitivity, specificity, NPV and PPV encourage utilization of PET/CT for locoregional staging of nonmetastatic breast carcinoma. The significant correlation between the primary tumor SUVmax value and grade, ER status, PR status and Ki-67 level increases the prognostic predictive value of the preoperative PET/CT. |
| Databáze: | OpenAIRE |
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