Clinical outcomes and utilization from over a decade of planned oocyte cryopreservation
| Autor: | Thomas L. Toth, Denny Sakkas, Denis A. Vaughan, Angela Q. Leung, Katherine Baker, Jaimin S. Shah, Ann Korkidakis, David A. Ryley |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty media_common.quotation_subject Fertility Cryopreservation 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Fertility preservation Birth Rate Retrospective Studies media_common 030219 obstetrics & reproductive medicine Obstetrics business.industry Fertility Preservation Obstetrics and Gynecology Oocyte cryopreservation Oocyte Embryo transfer 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Oocytes Female business Live birth Developmental Biology Cohort study |
| Zdroj: | Reproductive BioMedicine Online. 43:671-679 |
| ISSN: | 1472-6483 |
| DOI: | 10.1016/j.rbmo.2021.06.024 |
| Popis: | Research question What is the clinical experience of patients who have undergone planned oocyte cryopreservation and oocyte thawing and warming? Design Retrospective observational cohort study. All women who completed planned oocyte cryopreservation at a single large university-affiliated fertility centre between June 2006 and October 2020 were identified, including the subset who returned to use their oocytes. Patients who underwent oocyte cryopreservation for medical reasons were excluded. Baseline demographics, oocyte cryopreservation and thawing–warming cycle parameters, and clinical outcomes, were extracted from the electronic medical record. The primary outcome was cumulative live birth rate (LBR), and secondary outcomes were cumulative clinical pregnancy rate (CPR), and CPR and LBR per transfer. Results were stratified by age at time of cryopreservation ( Results Of 921 patients who underwent planned oocyte cryopreservation, 68 (7.4%) returned to use their oocytes. Forty-six patients (67.6%) completed at least one embryo transfer. The CPR per transfer was 47.5% and LBR was 39.3%. The cumulative LBR per patient who initiated thawing–warming was 32.4%. Cycle outcomes were not significantly different in patients aged younger than 38 years and those aged 38 years or over. No patient aged 40 years or older (n = 6) was successful with their cryopreserved oocytes. Ten patients (14.7%) who were unsuccessful with their cryopreserved oocytes achieved a live birth using donor oocytes, with most (7/10) of these patients aged 38 years and older. Conclusion Only a small percentage of patients returned to use their oocytes, and 32% of those were able to achieve a live birth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect