FGF-23 Levels before and after Renal Transplantation
| Autor: | Dimitrios Memmos, Aikaterini Papagianni, Panagiotis Pateinakis, Domniki Economidou, Spyros Dovas |
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| Rok vydání: | 2009 |
| Předmět: |
Fibroblast growth factor 23
medicine.medical_specialty Article Subject Calcitriol business.industry lcsh:Surgery chemistry.chemical_element lcsh:RD1-811 Calcium medicine.disease Transplantation Excretion surgical procedures operative Endocrinology chemistry Internal medicine Clinical Study medicine Renal threshold Prospective cohort study business Hypophosphatemia medicine.drug |
| Zdroj: | Journal of Transplantation Journal of Transplantation, Vol 2009 (2009) |
| ISSN: | 2090-0015 2090-0007 |
| Popis: | Phosphatonin fibroblast growth factor-23 (FGF-23) is involved in phosphate (P) excretion and vitamin D metabolism. Recently, FGF-23 has been suggested to be responsible for the hypophosphatemia and inappropriately low calcitriol levels observed after renal transplantation. We performed a prospective study to investigate FGF-23 levels in patients with end-stage renal disease before and after renal transplantation and their probable association with markers of bone and mineral metabolism. Intact FGF-23 levels were determined before and at 3, 6, and 12 months posttransplantation in 18 renal transplant recipients. Intact parathyroid hormone (iPTH), calcium (Ca), P, 25(OH)VitD, and 1,25 ( O H ) 2 VitD levels were measured at the same time periods. Renal threshold phosphate concentration ( T m P O 4 /GFR) was also calculated at 3, 6, and 12 months posttransplantation. The results showed that FGF-23 levels decreased by 89% 3 months posttransplantation (346 ± 146 versus 37 ± 9 pg/mL, 𝑃 < . 0 1 ) and remained stable throughout the study period. iPTH and P levels also decreased significantly after renal transplantation, while Ca and 1,25 ( O H ) 2 VitD increased. Pretransplantation FGF-23 was significantly correlated with P levels at 3 months posttransplantation ( 𝑃 < . 0 0 5 ). In conclusion, FGF-23 levels decrease dramatically after successful renal transplantation. Pre-transplantation FGF-23 correlate with P levels 3 months posttransplantation. |
| Databáze: | OpenAIRE |
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