The cancer genome anatomy project: online resources to reveal the molecular signatures of cancer
| Autor: | Carl F. Schaefer, Robert L. Strausberg, Kenneth H. Buetow, Susan F. Greenhut, Lynette H. Grouse |
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| Rok vydání: | 2002 |
| Předmět: |
Genetic Markers
Cancer Research Emerging technologies media_common.quotation_subject Molecular Sequence Data Context (language use) Genomics Computational biology Biology medicine.disease_cause Neoplasms Sequence Homology Nucleic Acid medicine Biomarkers Tumor Humans Function (engineering) Cancer Genome Anatomy Project media_common Oligonucleotide Array Sequence Analysis Genetics Expressed Sequence Tags Base Sequence Genome Human Cancer General Medicine medicine.disease Molecular analysis Oncology Carcinogenesis |
| Zdroj: | Cancer investigation. 20(7-8) |
| ISSN: | 0735-7907 |
| Popis: | Four years ago, the National Cancer Institute implemented the Cancer Genome Anatomy Project (CGAP), which was designed to build an interface between genomics and cancer research. It was evident that new approaches to science, based on comprehensive molecular analysis, promised remarkable new opportunities to enhance our fundamental understanding of cancer. New technologies offered the potential to delineate specific types of genetic changes, including patterns of altered gene expression and function that could be used to define any cancer in the context of, but not strictly dependent upon, its site of origin. Therefore, we anticipated that these new technologies would elucidate the molecular features of an individual tumor, and profile progression and response to therapy. The molecular information generated could be used by basic and clinical researchers to define the molecular signatures that distinguish different cancers.Pivotal to this approach is the availability of a robust database and analysis tool... |
| Databáze: | OpenAIRE |
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